We report an unusual association of peroneal mononeuropathy at the fibular head and the use of antithrombotic stockings. A patient developed clinical evidence of a peroneal nerve deficit temporally related to the use of a tight-fitting antithrombotic stocking. Nerve conduction studies and needle electromyography were performed. A peroneal mononeuropathy at the fibular head was confirmed and demonstrated mixed axonal and demyelinatmg features. Antithrombotic stockings are an unusual cause of peroneal mononeuropathy, Early recognition of this complication may improve outcome.