Thrombotic thrombocytopenic purpura unresponsive to plasma infusion and plasma exchange, but responsive to splenectomy
作者:
A. D. Sturgess,
B. H. Chong,
期刊:
European Journal of Haematology
(WILEY Available online 1986)
卷期:
Volume 37,
issue 4
页码: 319-322
ISSN:0902-4441
年代: 1986
DOI:10.1111/j.1600-0609.1986.tb02320.x
出版商: Blackwell Publishing Ltd
关键词: TTP;plasma infusion;plasma exchange;splenectomy
数据来源: WILEY
摘要:
A 60‐yr‐old female presented with typical thrombotic thrombocytopenic purpura (TTP). She remained in coma with frequent seizures for 1 wk, with persisting severe thrombocytopenia and microangiopathic haemolytic anaemia, despite treatment with prednisolone, plasma exchange, fresh frozen plasma, sulphinpyrazone and dipyridamole. Splenectomy induced haematological improvement within 1 d, there was cessation of fitting after 2 d, and full neurological recovery ensued over 3 wk. Laboratory studies did not reveal the presence of a platelet‐aggregating factor (PAF), stated to be present in some two‐thirds of cases. While plasma exchange and plasma infusion are beneficial in many cases, splenectomy appears still to be of value in unresponsive
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