Investigations of the cytoprotective effect of the gut stimulating principle ofCroton penduliflorushutch. Seed oil in rats
作者:
I. U. Asuzu,
S. N. Shetty,
S. M. Anika,
期刊:
Phytotherapy Research
(WILEY Available online 1989)
卷期:
Volume 3,
issue 1
页码: 33-35
ISSN:0951-418X
年代: 1989
DOI:10.1002/ptr.2650030109
出版商: John Wiley&Sons, Ltd.
关键词: CP crystals;cytoprotection;ulcer
数据来源: WILEY
摘要:
AbstractIndomethacin (10 mg/kg, p.o.) was used to induce gastric and duodenal ulcers of varying severity (scored as 1–9) in albino rats.Croton penduliflorusseed oil crystals (CP crystals) were administered to groups of rats at varying doses (6, 12, and 18mg/kg, p.o.). The ulcers observed in groups treated with indomethacin and CP crystals consisted mainly of the hyperemic conditions with one or two lesions (scored as 1–3) and medium sized lesions of moderate depth (scored as 4–6). Severe lesions with large diameter and depth (scored as 7–9 severity) observed in the control group treated with indomethacin only were absent in indomethacin and CP crystals treated groups. CP crystals offered significant (p<0.05) protection against gastric ulcers when given at 12 mg/kg and against duodenal ulcers when given at 6, 12 and 18 mg/kg. The maximum cytoprotection against duodenal ulcers was observed in rats treated with 18 mg/kg of CP c
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