Acute accidental overdosage of haloperidol in children
作者:
Ichiro Yoshida,
Yusuke Sakaguchi,
Toyojiro Matsuishi,
Eiji Yano,
Yushiro Yamashita,
Satoshi Hayata,
Taizo Hitoshi,
Fumio Yamashita,
期刊:
Acta Pædiatrica
(WILEY Available online 1993)
卷期:
Volume 82,
issue 11
页码: 877-880
ISSN:0803-5253
年代: 1993
DOI:10.1111/j.1651-2227.1993.tb12584.x
出版商: Blackwell Publishing Ltd
关键词: Haloperidol overdosage. toxic reactions
数据来源: WILEY
摘要:
We report the details of an accidental overdosage of haloperidol in 24 children in one hospital in Kyushu, Japan. Evidence of acute toxicity included disturbances in consciousness (24/24), tremors in the extremities (16/24), an oculogyric or similar crisis (14/24), dysarthria (9/17), drooling (8/24), akathisia (6/20), hyperreflexia (6/24) and opisthotonos (3/24). Laboratory examinations revealed late‐onset transient thrombocytosis (5/24), elevated AST and GPT (1/24) and abnormal ECG with prolonged QT interval in 2 of 8 children. We detected haloperidol in 11 of 18 children whose blood was specifically examined within four days after the final haloperidol administration. The maximum serum haloperidol level was 28.9 ng/ml. The mean half‐life of haloperidol in the serum of five children (age range 2–10 years) was 18.6 ± 12.2 h (mean ± SD) (range 9.1
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