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Acute accidental overdosage of haloperidol in children

 

作者: Ichiro Yoshida,   Yusuke Sakaguchi,   Toyojiro Matsuishi,   Eiji Yano,   Yushiro Yamashita,   Satoshi Hayata,   Taizo Hitoshi,   Fumio Yamashita,  

 

期刊: Acta Pædiatrica  (WILEY Available online 1993)
卷期: Volume 82, issue 11  

页码: 877-880

 

ISSN:0803-5253

 

年代: 1993

 

DOI:10.1111/j.1651-2227.1993.tb12584.x

 

出版商: Blackwell Publishing Ltd

 

关键词: Haloperidol overdosage. toxic reactions

 

数据来源: WILEY

 

摘要:

We report the details of an accidental overdosage of haloperidol in 24 children in one hospital in Kyushu, Japan. Evidence of acute toxicity included disturbances in consciousness (24/24), tremors in the extremities (16/24), an oculogyric or similar crisis (14/24), dysarthria (9/17), drooling (8/24), akathisia (6/20), hyperreflexia (6/24) and opisthotonos (3/24). Laboratory examinations revealed late‐onset transient thrombocytosis (5/24), elevated AST and GPT (1/24) and abnormal ECG with prolonged QT interval in 2 of 8 children. We detected haloperidol in 11 of 18 children whose blood was specifically examined within four days after the final haloperidol administration. The maximum serum haloperidol level was 28.9 ng/ml. The mean half‐life of haloperidol in the serum of five children (age range 2–10 years) was 18.6 ± 12.2 h (mean ± SD) (range 9.1

 

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