Platelet P-Selectin Expression Is Associated With Atherosclerotic Wall Thickness in Carotid Artery in Humans
作者:
Hidenori Koyama,
Takaaki Maeno,
Shinya Fukumoto,
Takuhito Shoji,
Takahisa Yamane,
Hisayo Yokoyama,
Masanori Emoto,
Tetsuo Shoji,
Hideki Tahara,
Masaaki Inaba,
Masayuki Hino,
Atsushi Shioi,
Takami Miki,
Yoshiki Nishizawa,
期刊:
Circulation: Journal of the American Heart Association
(OVID Available online 2003)
卷期:
Volume 108,
issue 5
页码: 524-529
ISSN:0009-7322
年代: 2003
出版商: OVID
关键词: atherosclerosis;cell adhesion molecules;diabetes mellitus;platelets
数据来源: OVID
摘要:
Background—Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects.Methods and Results—Unrelated subjects (n=517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with hyperlipidemia, were enrolled in the study. P-selectin expression was determined by whole-blood flow cytometry. Arterial stiffness (stiffness index &bgr;) and arterial wall thickness (intima-media thickness [IMT]) were determined by carotid ultrasound. P-selectin expression was significantly and positively correlated with carotid IMT and stiffness index &bgr;. Multiple regression analyses showed that the association of the percentage of P-selectin–positive platelets with carotid IMT was independent of other clinical factors. Moreover, the percentage of P-selectin–positive platelets was higher in subjects with carotid plaque and was an independent factor associated with occurrence of carotid plaque analyzed by multiple logistic regression analysis. Finally, the percentage of P-selectin–positive platelets was positively associated with age, body mass index, systolic and diastolic blood pressure, and HbA1c and inversely associated with HDL cholesterol.Conclusions—Platelet P-selectin is independently associated with atherosclerotic arterial wall changes in human subjects.
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