Cyclosporin and the gingival tissues
作者:
R. A. Seymour,
D. J. Jacobs,
期刊:
Journal of Clinical Periodontology
(WILEY Available online 1992)
卷期:
Volume 19,
issue 1
页码: 1-11
ISSN:0303-6979
年代: 1992
DOI:10.1111/j.1600-051X.1992.tb01140.x
出版商: Blackwell Publishing Ltd
关键词: cyclosporine;pharmacokinetics;pharmacodynamics;uses;unwanted effects;gingival overgrowth
数据来源: WILEY
摘要:
AbstractCyclosporin is a selective immunosuppressant that has a variety of applications in medical practice. Like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. This review considers the pharmacokinetics, pharmacodynamics, uses and unwanted effects of Cyclosporin, in particular the action of the drug on the gingival tissues. Clinical and cell culture studies suggest that the mechanism of gingival overgrowth is a result of an interaction between the drug and its metabolites with susceptible gingival fibro‐blasts. Plaque‐induced gingival inflammation appears to enhance this interact
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