Pharmacokinetics of Fosfomycin during Hemodialysis
作者:
F. Dalet,
G. Bade,
M. Roda,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 1
页码: 210-216
ISSN:0009-3157
年代: 1977
DOI:10.1159/000222050
出版商: S. Karger AG
关键词: Fosfomycin;Hemodialysis
数据来源: Karger
摘要:
A study was made of the elimination of fosfomycin by the membrane of the artificial kidney in 10 patients with hemodialysis and a creatinine clearance of less than 5 ml/min. To do so we determined the half-life, the dialysance, the percentage of total loss and the percentage of loss by the artificial kidney. We reached the conclusion that fosfomycin is heavily dialyzed (D = 64 ml/min), it is entirely eliminated by the kidneys and its half-life is therefore affected very little (an increase of only about 30 min is produced). All of this leads to a practical schema by which the entire initial dose should be replenished at the end of each dialysis.
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