Chronic Treatment with Imipramine Does Not Reverse the Effects of 3 Anxiogenic Compounds in a Test of Anxiety in the Rat
作者:
Sandra E. File,
Amanda L. Johnston,
期刊:
Neuropsychobiology
(Karger Available online 1987)
卷期:
Volume 17,
issue 4
页码: 187-192
ISSN:0302-282X
年代: 1987
DOI:10.1159/000118363
出版商: S. Karger AG
关键词: Anxiety;Panic;Antidepressants;Imipramine;β-Carbolines
数据来源: Karger
摘要:
The ability of chronic treatment with imipramine (an antidepressant with anti-panic activity) to antagonise the anxiogenic effects of 3 different compounds was investigated in the elevated plus-maze. The compounds chosen are likely to produce anxiety by activity at different sites in the central nervous system: yohimbine, by blocking the α2-adrenoceptor; FG 7142, by action at the β-carboline site on the GABA-benzodiazepine receptor complex and pentylenetetrazole, by acting at the picrotoxinin site on this complex. Administration of imipramine following 21 days pre-treatment did not produce a significant consistent anxiolytic effect alone and was unable to reverse the anxiety produced by any of the 3 anxiogenic compounds. Our results are discussed in terms of the nature of the anxiety produced by the anxiogenic drugs and the sensitivity of tests of anxiety to anti-panic agent
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