Tumor Necrosis Factor in Advanced Colorectal Cancer: A Phase II Study
作者:
M.E. Heim,
R. Siegmund,
H.J. Illiger,
M. Klee,
K. Rieche,
W.E. Berdel,
L. Edler,
期刊:
Onkologie
(Karger Available online 1990)
卷期:
Volume 13,
issue 6
页码: 444-447
ISSN:0378-584X
年代: 1990
DOI:10.1159/000216817
出版商: S. Karger GmbH
关键词: Tumor necrosis factor;Colorectal carcinoma;Phase II study
数据来源: Karger
摘要:
In a phase II study, the efficacy and toxicity of human recombinant tumor necrosis factor (rh TNF-alpha) were evaluated in patients with advanced colorectal carcinoma. Rh TNF-alpha was given as short term infusion at a dose of 3 × 105 U/m2 on three successive days. Treatment was repeated after a two week interval. The response was evaluated after four treatment cycles. In 15 patients entering the study, we found one partial response, one stable disease, 9 progressive diseases, and four patients who where not evaluable for tumorremission. There were numerous side effects of the treatment, mainly fever, chills, loss of appetite, leukopenia, and hepatotoxicity. In this regimen, rh TNF-alpha does not suggest a therapeutic advantage for treatment of advanced colorectal carcinoma
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