Calcium Metabolism in the Normal and Failing Heart
作者:
ChidseyCharles A.,
期刊:
Hospital Practice
(Taylor Available online 1972)
卷期:
Volume 7,
issue 8
页码: 65-75
ISSN:2154-8331
年代: 1972
DOI:10.1080/21548331.1972.11706240
出版商: Taylor&Francis
数据来源: Taylor
摘要:
An abnormality in calcium flux is more likely to account for the depressed contractility of failing myocardium than any other biochemical defect; studies at the molecular level are gradually delineating the specific nature of the abnormality. It has become clear that mitochondrial uptake of calcium is increased in the failing myocardial cell, with profound effects on the amount available to initiate contraction.
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