Two Autopsy Cases of Pick's Disease with Neurofibrillary Tangles
作者:
Katsusuke Mitsunobu,
Hiroshi Ishino,
期刊:
Psychiatry and Clinical Neurosciences
(WILEY Available online 1982)
卷期:
Volume 36,
issue 1
页码: 89-98
ISSN:1323-1316
年代: 1982
DOI:10.1111/j.1440-1819.1982.tb00259.x
出版商: Blackwell Publishing Ltd
关键词: Pick's disease;neurofibrillary tangles;Alzheimer's disease
数据来源: WILEY
摘要:
Abstract:Two cases of presenile dementia were presented. Both showed “stehende Redensarten” and aphasia. Histopathologically, besides Pick features–temporal lobe atrophy, fibrillary gliosis of the temporal white matter and neuronal loss in the 2–3 cortical layers–, Alzheimer features–neurofibrillary tangles and granulo‐vacuolar degeneration–were found in both cases. But no senile plaques were found. Pseudocalcaerous deposits were observed in the cerebral cortex, basal ganglia and cerebellum. Atypical cases with both Pick's and Alzheimer's diseases in the literature were classified into four groups according to the extent of the features of each disease. Sensory aphasia, which is relatively unusual in Pick's disease, was correlated to the atrophy of left Tl, and similar cases in the literatur
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