A Simple Technique to Manage Malignant Pericardial Effusion with a Local Instillation of Bleomycin in Non-Small Cell Carcinoma of the Lung
作者:
Tokujiro Yano,
Hideki Yokoyama,
Takashi Inoue,
Nobuko Takanashi,
Hiroshi Asoh,
Yukito Ichinose,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 6
页码: 507-509
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227394
出版商: S. Karger AG
关键词: Cardiac tamponade;Local treatment;Pericardial drainage;Bleomycin;Lung cancer;Malignant pericardial effusion
数据来源: Karger
摘要:
To examine the efficacy of bleomycin on the local control of malignant pericardial effusion, we prospectively conducted a clinical trial consisting of continuous pericardial drainage and a local instillation of bleomycin. In the current study, we treated 7 patients, who suffered from malignant pericardial effusion with cardiac tamponade due to advanced-stage non-small cell carcinoma of the lung. The pericardial effusions were continuously drained through an echo-guided inserted catheter. After the effusions were drained as completely as possible, 5 mg of bleomycin were instilled locally via the catheter. In all patients but one, the draining catheter could be successfully removed. The duration of drainage ranged from 4 to 13 days (mean: 9.2 days). Five of the 7 patients achieved a complete remission of pericardial effusions, which was maintained until death or the last day of follow-up. Intrapericardial bleomycin treatment was thus found to be effective on malignant pericardial effusions without any adverse effects. However, a further study comparing the effect of pericardial instillation of bleomycin versus drainage alone would be needed for the determination of the usefulness of bleomycin.
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