Studies on the mechanism of cartilage degradation
作者:
Y. M. Sin,
A. D. Sedgwick,
D. A. Willoughby,
期刊:
The Journal of Pathology
(WILEY Available online 1984)
卷期:
Volume 142,
issue 1
页码: 23-30
ISSN:0022-3417
年代: 1984
DOI:10.1002/path.1711420107
出版商: John Wiley&Sons, Ltd.
关键词: Cartilage degradation;proteoglycans;collagen
数据来源: WILEY
摘要:
AbstractAnin vivostudy of cartilage breakdown in mice was carried out by implanting living and dead, intact or finely minced autologous cartilage back into newly elicited inflammatory tissue of the original donor. At various time intervals, the implants were removed and their loss of proteoglycan and collagen analysed both histologically and biochemically. The results show that only a modest loss of proteoglycan and collagen occurs in the living intact cartilage. Severe loss of proteoglycan was detected in the minced living and dead intact cartilage. The present findings clearly demonstrate that mechanical damage during the mincing of cartilage predisposes this tissue to attack by various types of mediators known to degrade cartilage.
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