Clinical Application of Epiderm Growth Factor in Patients with Most Severe Eye Burns
作者:
M. Reim,
T. Kehrer,
M. Lund,
期刊:
Ophthalmologica
(Karger Available online 1988)
卷期:
Volume 197,
issue 4
页码: 179-184
ISSN:0030-3755
年代: 1988
DOI:10.1159/000309941
出版商: S. Karger AG
关键词: Alkali burn;Regeneration;Cornea;Epithelium;Epiderm growth factor;Fibronectin
数据来源: Karger
摘要:
20 eyes of 11 patients suffering from most severe eye burns of grade 4 or worse were treated in addition to various other drugs with epiderm growth factor (EGF) or placebo in a double-blind test. Among 10 eyes treated with EGF, 6 achieved complete regeneration of the corneal epithelium, and 1 additional case, of the conjunctival epithelium. Among the eyes receiving placebo, only 3 out of 10 healed; all of them were also treated with fibronectin. Although in these very difficult cases EGF could not be investigated as a single therapy, and various other undefined factors may have been effective, in the extended course of the disease the period of EGF treatment was marked by a significant better regeneration of the epithelium.
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