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Hyperuricemic Nephropathy: Pathologic Features and Factors Influencing Urate Deposition

 

作者: James R. Klinenberg,   Ian Kippen,   Rodney Bluestone,  

 

期刊: Nephron  （Karger Available online 1975）
卷期: Volume 14, issue 1  

页码: 88-98

 

ISSN:1660-8151

 

年代: 1975

 

DOI:10.1159/000180438

 

出版商: S. Karger AG

 

关键词: Gouty Nephropathy;Acute Hyperuricemic Nephropathy;Uric Acid Nephrolithiasis;Urate Solubility;Urate Protein Binding;Uricosuric Drugs;Experimental Hyperuricemic Nephropathy

 

数据来源: Karger

 

摘要:

The three general types of renal pathology associated with hyperuricemia are reviewed. Factors influencing urate solubility are discussed, as well as the effect of uricosuric drugs on renal urate handling, with particular emphasis upon their efficacy in competing with urate for protein binding sites. In addition, a new experimental model of hyperuricemic nephropathy is described which could yield valuable data concerning the complex relationships between hyperuricemia, urate deposition and renal function.

 

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