Protein Metabolism in Uraemia
作者:
Peter Richards,
期刊:
Nephron
(Karger Available online 1975)
卷期:
Volume 14,
issue 2
页码: 134-152
ISSN:1660-8151
年代: 1975
DOI:10.1159/000180444
出版商: S. Karger AG
关键词: Protein metabolism;Uraemia;Nitrogen reutilization;Essential amino acids
数据来源: Karger
摘要:
Protein metabolism in uraemia is reviewed. Very few, if any, disorders of amino acid metabolism can at present confidently be attributed to uraemia per se rather than to protein/energy deprivation. Retained urea nitrogen is recycled to the liver as ammonia; a proportion is reutilized for synthesis of non-essential amino acids and, if their carbon skeletons are supplied, for synthesis of essential amino acids. Practical applications of the reutilization of non-amino nitrogen in advanced chronic renal failure are being explored. Nevertheless, uraemic individuals readily become undernourished, and they should receive as much protein as their symptoms will permit.
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