Preparation of radiolabeled pregnenolone analogs. 21‐Fluoro‐ pregnenolone‐21‐18F, 21‐fluoropregnenolone‐3‐acetate‐21‐18F, 21‐fluoropregnenolone‐7‐3H, and 21‐fluoropregnenolone‐3‐acetate‐7‐3H
作者:
Robert R. Eng,
Larry A. Spitznagle,
William F. Trager,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1983)
卷期:
Volume 20,
issue 1
页码: 63-72
ISSN:0362-4803
年代: 1983
DOI:10.1002/jlcr.2580200109
出版商: John Wiley&Sons, Ltd.
关键词: 21‐Fluoropregnenolone‐21‐18F;21‐Fluoropregnenolone‐3‐ ‐acetate‐21‐18F;21‐Fluoropregnenolone‐7‐3H;21‐Fluoropregnenolone‐3‐acetate‐7‐3H;18‐Crown‐6;Fluorine‐18
数据来源: WILEY
摘要:
Abstract21‐Fluoropregnenolone‐3‐acetate‐21‐18F (4b) and 21‐fluoropregnenolone‐21‐18F (8) were synthesized by nucleophilic substitution of the iodo group of the corresponding 21‐iodo analogs by F‐fluoride in an acetonitrile solution of 18‐Crown‐6. 21‐Fluoropregnenolone‐3‐acetate‐ 7‐3H (10b) and 21‐fluoropregnenolone‐7‐3H (9b) were synthesized by reacting 21‐ethoxalyl pregne
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