The authors report on the myocardiopathy of seven patients with end-stage renal disease, characterized by fever, in four patients; tachycardia, gallop rhythm, pericardial rub, in most of patients; signs and symptoms of cardiac failure and increased cardiac area and alterations of the EKG in all patients. Good remission of the symptoms was achieved in two patients by hemodialysis and by successful renal transplantation in the others. The likely etiologic factors of the syndrome are discussed.