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Von Willebrand Factor Abnormalities and Endothelial Cell Perturbation in a Patient with Acute Thrombotic Thrombocytopenic Purpura

 

作者: JOEL MOAKE,   CHRISTINE RUDY,   JOSEPH TROLL,   MARK WEINSTEIN,   NOREEN COLANNINO,   SUCHEN HONG,   JASON KOUTCHER,   ANTHONY MELARAGNO,   CHARLES MANNER,  

 

期刊: The American Journal of the Medical Sciences  （OVID Available online 1986）
卷期: Volume 291, issue 1  

页码: 47-50

 

ISSN:0002-9629

 

年代: 1986

 

出版商: OVID

 

关键词: von Willebrand factor;Endothelial cells;Acute thrombotic thrombocytopenic purpura

 

数据来源: OVID

 

摘要:

The plasma of a 63-year-old patient with an initial acute, fatal episode of thrombotic thrombocytopenic purpura (TTP) contained agglutinated platelets and a factor VIII-related von Willebrand factor (vWF) antigen level that was elevated sevenfold above normal. Unusually large vWF multimers derived from endothelial cells were detected in her plasma at the on set of the TTP episode. This is the first patient in whom vWF abnormalities indicative of in vivo endothelial cell damage or perturbation have been found during an acute episode of TTP.

 

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