Dipetalonema viteaeinfection in three species of rodents: species specific patterns of the antibody response
作者:
R. LUCIUS,
A. KAPAUN,
H. J. DIESFELD,
期刊:
Parasite Immunology
(WILEY Available online 1987)
卷期:
Volume 9,
issue 1
页码: 67-80
ISSN:0141-9838
年代: 1987
DOI:10.1111/j.1365-3024.1987.tb00489.x
出版商: Blackwell Publishing Ltd
关键词: Dipetalonema viteae;Meriones unguiculatus;Mastomys natalensis;Mesocricetus auratus;course of infection;immunoblotting technique;immune suppression;species specific antigen recognition
数据来源: WILEY
摘要:
SummaryGroups of jirds (Meriones unguiculatus), multimammate rats (Mastomys natalensis) and golden hamsters (Mesocricetus auratus) were infected with third stage larvae (L3) ofDipetaloneam viteaeand the course of infection was followed until 20 weeks post infection. Worm growth was best and microfilaraemia was high and long lasting in jirds and in multimammate rats, whereas golden hamsters were poor hosts as measured by these parameters. The IgG and IgM antibody responses of the species were compared by immunoblotting and ELISA using proteins ofD. viteae, separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE). The levels of antibodies against most proteins of high molecular weight declined during infection in jirds and in multimammate rats, whereas an increase was observed in golden hamsters. In contrast, several antigens of low molecular weight induced increasing antibody levels in all species. Species specific antigen recognition was observed for a number of protein bands of L3, microfilariae and female worms. The data suggest that susceptibility to immunesuppression and the species specific pattern of antigen recognition might determine the qualities of a rodent species as host forD. vitea
点击下载:
PDF
(1161KB)
返 回