Cerebral Blood Flow Abnormalities in Adults with Infantile Autism
作者:
MARK GEORGE,
DURVAL COSTA,
KYPROS KOURIS,
HOWARD RING,
PETER ELL,
期刊:
The Journal of Nervous and Mental Disease
(OVID Available online 1992)
卷期:
Volume 180,
issue 7
页码: 413-417
ISSN:0022-3018
年代: 1992
出版商: OVID
数据来源: OVID
摘要:
Stuctural brain abnormalities have recently been discovered using magnetic resonance imaging in infantile autism, a neurodevelopmental disorder of unknown etiology. However, functional neuroimaging studies in autism using positron emission tomography have had conflicting results and have not explained how the known structural brain abnormalities in autism act in a functioning brain to produce autistic behavior. Using a new technology, highresolution brain single photon emission tomography, we studied and scanned four young adults with infantile autism and four age-matched controls using the labeled ligand99mTc-D,Lhexamethyl- propylene amine oxime (99mTc-HMPAO). Total brain perfusion was significantly decreased in autism subjects (range, 58% to 72% of controls,p≤.02). In addition to the globally decreased perfusion, the autism group also had regionally decreased flow in the right lateral temporal and right, left, and midfrontal lobes compared with controls (p≤.02, Mann- Whitneyt-test).
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