Time-Dependent Changes in Platelet Aggregation, Fibrinolytic Activity, and Peripheral Serotonergic Measures in Rats Subjected to Water Immersion Restraint Stress
作者:
J. Malyszko,
T. Urano,
Y. Takada,
A. Takada,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1994)
卷期:
Volume 24,
issue 4
页码: 236-242
ISSN:1424-8832
年代: 1994
DOI:10.1159/000217107
出版商: S. Karger AG
关键词: Tissue plasminogen activator;Plasminogen activator inhibitor;Serotonin;Platelet aggregation;Stress
数据来源: Karger
摘要:
The effects of water immersion restraint stress on collagen-induced platelet aggregation in whole blood, and on the fibrinolytic and serotonergic systems in rats have been studied. One hour long stress caused a release of tissue plasminogen activator (tPA) into the blood and a shortening of euglobulin clot lysis time (ECLT), whereas restraint of longer duration was responsible for a reduction in platelet aggregation, an elevation in the activity of plasminogen activator inhibitor with a concomitant fall in tPA and a prolongation of ECLT relative to controls. Whole-blood and plasma serotonin and its metabolite 5-hydroxyindoleacetic acid were also higher in the stressed rats and whole-blood serotonin level showed a negative correlation with tPA in the stressed rats. Either stress and/ or its duration are responsible for changes in both fibrinolytic and serotonergic systems.
点击下载:
PDF
(2560KB)
返 回