Acute hepatitis non‐A, non‐B; are there any specific light microscopic features?
作者:
Martin Schmid,
Mauro Pirovino,
Josef Altorfer,
Fred Gudat,
Leonardo Bianchi,
期刊:
Liver
(WILEY Available online 1982)
卷期:
Volume 2,
issue 1
页码: 61-67
ISSN:0106-9543
年代: 1982
DOI:10.1111/j.1600-0676.1982.tb00179.x
出版商: Blackwell Publishing Ltd
关键词: viral hepatitis;acute hepatitis non‐A;non‐B: light microscopy
数据来源: WILEY
摘要:
ABSTRACT—Coded examination of liver biopsies from a total of 24 patients with acute hepatitis non‐A, non‐B revealed two main histological trends: (a) acute viral hepatitis with confluent necrosis (sublobular and bridging) carrying a relatively good prognosis and taking a chronic course in only four out of 14 patients (29%); and (b) acute viral hepatitis with severe portal infiltration rich in lymphocytes and plasma cells, lymph follicles with germinal centers and bile duct lesions, as described by Poulsen&Christoffersen. The latter group showed a very high tendency to transition to chronic hepatitis (six out of seven patients, 86%) or a course characterized by one or multiple acute relapses (one out of seven patients, 14%). Bile duct lesions, if present in biopsies of patients with acute hepatitis, are of diagnostic and prognostic value. They point to the etiological possibility of a hepatitis non‐A, non‐B and, at the same time, they indicate a high likelihood of evolution to chronic live
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