Cholinergic Challenges in Affective IllnessBehavioral and Neuroendocrine Correlates
作者:
SAMUEL,
RISCH NED,
KALIN DAVID,
期刊:
Journal of Clinical Psychopharmacology
(OVID Available online 1981)
卷期:
Volume 1,
issue 4
页码: 186-192
ISSN:0271-0749
年代: 1981
出版商: OVID
数据来源: OVID
摘要:
&NA;The cholinergic‐adrenergic balance hypothesis of affective disorders suggests that, in the areas of the brain that regulate mood, depression may represent a relative predominance of central cholinergic tone over adrenergic tone and that mania may represent the converse. Currently, converging lines of investigation from a number of independent groups suggest that affective disorder patients may have a central cholinergic receptor hypersensitivity that induces a vulnerability to affective and neuroendocrine disturbances. This article reviews the evidence for cholinergic mechanisms in the regulation of affective state and describes current research strategies using centrally active cholinomimetic agents to explore disturbances in affective disorder subjects.
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