We describe a patient who in association with myeloma developed generalized keratotic horns. Light microscopy revealed parakeratotie plugs resembling those seen in Kyrle's disease. Electron microscopy showed distortion of keratinosomes and laminated bodies indicating a profund disturbance in keratinization. A strong C3and weaker IgG and IgA immunofluoresence were seen in the areas of epidermal plugs and horns but no circulating epidermal antibodies were detected. All symptoms disappeared when therapy for myeloma was started favoring that (hey were of paraneoplastic origin.