Use of Verapamil with Conventional Immunosuppression after Porcine Renal Transplantation
作者:
D. Kahn,
Rosemary Hickman,
C. Dreyer,
C. Temple Camp,
期刊:
European Surgical Research
(Karger Available online 1989)
卷期:
Volume 21,
issue 3-4
页码: 156-161
ISSN:0014-312X
年代: 1989
DOI:10.1159/000129018
出版商: S. Karger AG
关键词: Verapamil;Immunosuppression
数据来源: Karger
摘要:
It has recently been suggested that the use of calcium channel-blocking agents may improve the results of renal transplantation either by enhancing the immunosuppressive effects of ciclosporin, or by improving posttransplant acute renal failure. In the present study, unlike others, verapamil was administered to the animals for 10 days posttransplant, alone or in conjunction with ciclosporin and/or solumedrol. In the group in which all three agents were given together, there were minimal changes in plasma urea or creatinine for the 10 days after transplantation. However, survival and the histological appearances of the kidneys at autopsy showed no improvement as compared with those in animals treated with ciclosporin and steroids. There is thus no evidence from this study to suggest that verapamil could advantageously be added to a clinical immunosuppressive regime.
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