In vitrostudies of the interaction between heparin and eosinophil cationic protein
作者:
K. Fredens,
R. Dahl,
P. Venge,
期刊:
Allergy
(WILEY Available online 1991)
卷期:
Volume 46,
issue 1
页码: 27-29
ISSN:0105-4538
年代: 1991
DOI:10.1111/j.1398-9995.1991.tb00538.x
出版商: Blackwell Publishing Ltd
关键词: eosinophil cationic protein;heparin;in vitrotest;plasma coagulation
数据来源: WILEY
摘要:
Eosmophil cationic protein (ECP) is a protein specific to the granules of human eosinophil granulocytes. ECP is highly cationic and may damage tissue if not inactivated. Heparin is a highly anionic substance present in mast cells and basophil granulocytes. The presentin vitrostudy shows that ECP can inactivate the anticoagulant activity of heparin probably by the formation of a complex between the two molecules. This function may be of importance for the microenvironment of allergic diseases where secretion of heparin may promote penetration of mast cell products through tissues. Also this may constitute one mechanism whereby the cytotosic action of ECP is neutralized.
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