Administration of Lithium to Rats by Different Routes
作者:
Vendelin Olesen,
Mogens Schou,
Klaus Thomsen,
期刊:
Neuropsychobiology
(Karger Available online 1976)
卷期:
Volume 2,
issue 2-3
页码: 134-138
ISSN:0302-282X
年代: 1976
DOI:10.1159/000117541
出版商: S. Karger AG
关键词: Lithium administration;Lithium absorption;Intraperitoneal injection;Subcutaneous injection;Gastric tube
数据来源: Karger
摘要:
Rats were given identical doses of lithium chloride, 4 mmol/kg body weight/day for 8 days, by different routes. Intraperitoneal administration led to a high serum lithium peak and the development of pronounced polyuria-polydipsia. Subcutaneous administration led to a lower serum peak and the development of less pronounced polyuria-polydipsia. Administration by gastric tube led to a nearly constant serum lithium concentration without any peak and the development of moderate polyuria-polydipsia. Our study shows that the route by which lithium is administered affects the lithium concentration pattern and may influence lithium effects.
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