Drug Withdrawal in Chronic Schizophrenic Patientsin Search of Neuroleptic‐Induced Supersensitivity Psychosis
作者:
DANIEL,
WEINBERGER LLEWELLYN,
BIGELOW SUSAN,
KLEIN RICHARD,
期刊:
Journal of Clinical Psychopharmacology
(OVID Available online 1981)
卷期:
Volume 1,
issue 3
页码: 120-123
ISSN:0271-0749
年代: 1981
出版商: OVID
数据来源: OVID
摘要:
&NA;As a test of the hypothesis that neuroleptics can induce a psychosis secondary to dopamine receptor supersensitivity, we examined the behavioral ratings of 20 symptomatic chronic schizophrenic patients who were withdrawn from neuroleptic drugs and maintained drug free for 4 wk. We hypothesized that, if supersensitivity existed, it might be reflected in a drug‐free course characterized by an initial phase of exacerbation followed by improvement (a “hump”). Four patients had such a course. No patient had the inverse of this hypothesized course (improvement followed by relapse). The implications of this finding and problems inherent in testing the supersensitivity psychosis hypothesis are discussed.
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