The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study. II. Endocrine correlates.
作者:
LondonR S,
SundaramG,
ManimekalaiS,
MurphyL,
ReynoldsM,
GoldsteinP,
期刊:
Journal of the American College of Nutrition
(Taylor Available online 1984)
卷期:
Volume 3,
issue 4
页码: 351-356
ISSN:0731-5724
年代: 1984
DOI:10.1080/07315724.1984.10720059
出版商: Routledge
数据来源: Taylor
摘要:
In a randomized, double-blind, dose-response study, alpha-tocopherol significantly ameliorated symptoms in three of the four classes of the premenstrual syndrome (PMS). Alpha-tocopherol treatment had no significant effect on serum concentrations of testosterone, dehydroepiandrosterone sulfate (DHEA-S), estradiol, and progesterone. However, independent of treatment, a significant correlation emerged between temporal changes in one PMS category and changes in DHEA-S concentrations. These results suggest that improvement in PMS severity is not mediated through direct effects of alpha-tocopherol on serum steroids. Androgens, however, may play a role in some PMS symptomatology.
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