Antibodies against lymphocyte surface components are able to rearrange profoundly the topography of the cell membrane with a differential modulation of surface antigens. Of particular interest is the effect of anti‐β2m reagents, which are able to suppress completely the reactivity of epitopes carried by the two chains of the ABC dimers, while the expressivity of other antigens, such as DR, is significantly increased. These results have been obtained with immunoradiobinding under a variety of conditions, thus confirming the validity of the “bb” (β2m blanketin