REACTIVITY OF AUTOLYMPHOCYTOTOXIC ANTIBODIES FROM DIALYSIS PATIENTS WITH LYMPHOCYTES FROM CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PATIENTS
作者:
ALAN TING,
PETER MORRIS,
期刊:
Transplantation
(OVID Available online 1978)
卷期:
Volume 25,
issue 1
页码: 31-33
ISSN:0041-1337
年代: 1978
出版商: OVID
数据来源: OVID
摘要:
SUMMARYAutolymphocytotoxic antibodies are found commonly in dialysis patients and these autoantibodies may be directed against T and B lymphocytes or just B lymphocytes. However, these autoantibodies react with a low frequency or not at all against chronic lymphocytic leukemia cells, and are not absorbed by autologous erythrocytes. Thus, a number of positive crossmatches between donor and recipient may be attributable to autoantibodies. Six renal transplants have been carried out in the presence of such a positive crossmatch against donor B lymphocytes, including one against donor T lymphocytes, with a successful graft outcome. Thus, the indications for renal transplantation in the presence of a positive cross-match between donor and recipient are becoming better defined.
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