Renal Biopsy and Family Studies in 65 Children with Isolated Hematuria
作者:
C. H. SCHRÖDER,
C. M. BONTEMPS,
K. J. M. ASSMANN,
J. H. SCHUURMANS STEKHOVEN,
J. M. FOIDART,
L. A. H. MONNENS,
J. H. VEERKAMP,
期刊:
Acta Pædiatrica
(WILEY Available online 1990)
卷期:
Volume 79,
issue 6‐7
页码: 630-636
ISSN:0803-5253
年代: 1990
DOI:10.1111/j.1651-2227.1990.tb11527.x
出版商: Blackwell Publishing Ltd
关键词: Alport syndrome;benign (familial) hematuria;renal biopsy;ultrastructure
数据来源: WILEY
摘要:
ABSTRACT.We have investigated 65 children with isolated hematuria persisting for at least a year. Renal biopsy specimens were studied by light microscopy, electron microscopy and immunofluorescence with antisera specific against basement membrane components. The majority of the biopsies (62/65) showed variable histologic abnormalities. Four categories could be distinguished on combined histological and clinical criteria: Alport syndrome (n=8), benign hematuria (n=33, familial in 23), IgA nephropathy (n = 16) and increase in mesangial cells and matrix (n=5). On the basis of our results, we suggest that a renal biopsy can establish diagnosis and prognosis in those children with isolated hematuria where the family history is negative. If the family has adult male individuals with isolated hematuria, a biopsy can usually be avoided, since this family history effectively excludes Alport syndrome. The use of antisera against basement membrane components did not allow a differentiation between Alport syndrome and benign hematuria. Goodpasture serum immunofluorescence was variable in the former and normally present in the latter.
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