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Inhibition of Activated Factors II, VII, IX, and X by Synthetic Organic Compounds Directed against the Active-Site Seryl Residue

 

作者: J.A. v.d. Woerd-de Lange,   M.C.E. van Dam-Mieras,   H.C. Hemker,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  （Karger Available online 1981）
卷期: Volume 10, issue 6  

页码: 315-347

 

ISSN:1424-8832

 

年代: 1981

 

DOI:10.1159/000214417

 

出版商: S. Karger AG

 

关键词: Thrombin;Factor VIIa;Factor IXa;Factor Xa;Inhibition;Organic compounds

 

数据来源: Karger

 

摘要:

A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.

 

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