Because of the complex functions of the human frontal lobes, rehabilitation of persons with frontal lobe injury presents a unique set of challenges. Evaluation of behavioral disturbances associated with frontal damage must be individualized and contextually based; neuropsychological assessment is helpful, but not sufficient. Treatment planning should be highly specific as to expected outcomes. Prosthetic environments and prosthetic supports, skill-based learning approaches, and other behavioral programming methods may be effective singly, or in combination, for minimizing the impact of frontal lobe deficits.