Human Recombinant Interferon Alpha-2a Inhibits Angiogenesis of Chick Area Vasculosa in Shell-Less Culture
作者:
D. Ribatti,
A. Vacca,
Monica Iurlaro,
R. Ria,
Luisa Roncali,
F. Dammacco,
期刊:
International Journal of Microcirculation
(Karger Available online 1996)
卷期:
Volume 16,
issue 4
页码: 165-169
ISSN:0167-6865
年代: 1996
DOI:10.1159/000179169
出版商: S. Karger AG
关键词: Area vasculosa;Anti-angiogenesis;Interferonα
数据来源: Karger
摘要:
In vivo suppression of neovascularization by in situ administration of human recombinant interferon α2a (hrlFN-α2a) was tested on the chick embryo area vasculosa (AV). Methylcellulose discs, each containing 5 IU of hrlFN-α2a were implanted onto the AV at Hamburger-Hamilton (HH) stage 13, and inhibition of blood vessel growth was morphometrically evaluated between HH stages 20 and 27. Our results show: (i) a decreased extent of the AV; (ii) a decreased AV total vessel length; (iii) modified percent ratios of different classes of AV vessels having a definite length. The observed effects of treating with hrlFN-α2a are likely attributable to inhibition of endothelial cell proliferat
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