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The Super‐Normal Control Group in Psychiatric GeneticsPossible Artifactual Evidence for Coaggregation

 

作者: Kenneth,  

 

期刊: Psychiatric Genetics  (OVID Available online 1990)
卷期: Volume 1, issue 2  

页码: 45-53

 

ISSN:0955-8829

 

年代: 1990

 

出版商: OVID

 

数据来源: OVID

 

摘要:

&NA;Recent family, twin and adoption studies of psychiatric illness have often used “super‐normal” control groups, from which individuals are excluded if they demonstrate any significant psychopathology. Relatives of such “super‐normal” control groups will have lower rates of psychiatric illness than the general population. Since such screening is not usually applied to index probands, rates of “screened‐out” disorders may be increased in relatives of index versus “super‐normal” control probands, producing spurious evidence for coaggregation. An algebraic model demonstrates that this artifactual coaggregation will be strongest for “screened‐out” disorders that are both highly familial and common in the population.

 

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