Characteristics of Polyester Arterial Grafts Coated with Albumin: The Role and Importance of the Cross-Linking Chemicals
作者:
S. Ben Slimane,
R. Guidoin,
D. Marceau,
Y. Merhi,
M.W. King,
M.-F. Sigot-Luizard,
期刊:
European Surgical Research
(Karger Available online 1988)
卷期:
Volume 20,
issue 1
页码: 18-28
ISSN:0014-312X
年代: 1988
DOI:10.1159/000128736
出版商: S. Karger AG
关键词: Polyester;Arterial graft;Glutaraldehyde;Carbodiimide;Albumin
数据来源: Karger
摘要:
Preclotting is mandatory prior to implanting a knitted polyester arterial graft, unless the structure is made impermeable to blood by coating with a bioerodible material. Before achieving wide-spread clinical acceptance, the technique of impregnating with cross-linked albumin must be optimized in order to develop a graft that is immediately implant-able, easy to handle and suture and has improved healing characteristics. The choice of the chemical to cross-link the albumin is of paramount importance. In this study two alternative candidates have been evaluated by using a series of tests to measure the physical properties, the morphology and the cytocompatibility of albumin-coated grafts. A carbodiimide cross-linking agent appears more promising than glutaraldehyde, since it is equally effective in producing a blood impermeable prosthesis, yet presents improved biocompatibility and provokes a less intense inflammatory response from the host.
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