首页   按字顺浏览 期刊浏览 卷期浏览 Antibacterial and Antifungal Activities of Nitroxoline Mannich Bases
Antibacterial and Antifungal Activities of Nitroxoline Mannich Bases

 

作者: M. Medić-Šarić,   D. Maysinger,   M. Movrin,   I. Dvoržak,  

 

期刊: Chemotherapy  （Karger Available online 1980）
卷期: Volume 26, issue 4  

页码: 263-267

 

ISSN:0009-3157

 

年代: 1980

 

DOI:10.1159/000237915

 

出版商: S. Karger AG

 

关键词: Nitroxoline;Mannich bases;Antibacterial activity;Antifungal activity

 

数据来源: Karger

 

摘要:

The in vitro activity of nitroxoline and its Mannich bases against bacteria and fungi was investigated. Nitroxoline and its derivative with diisopropylamine as an amino component, exhibited the highest antimicrobial activity. The optimum hydro/lipophilic properties (log P), both for antibacterial and antifungal activity, are about log P values of 2. The least effective compound was this nitroxoline Mannich base which has diethanolamine as an amino component.

 

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