Gastric Mucosal Cell Proliferation and Immunoglobulin-Containing Cells in Ménétrier’s Disease
作者:
Hart Hansen,
K.B. Jensen,
J.K. Larsen,
J. Søltoft,
期刊:
Digestion
(Karger Available online 1977)
卷期:
Volume 16,
issue 4
页码: 293-298
ISSN:0012-2823
年代: 1977
DOI:10.1159/000198081
出版商: S. Karger AG
关键词: Antrum;Cell division;Fundus;Gastric mucosa;Immunoglobulin;IgA;IgG;IgM;Plasma cells;Ménétriér’s disease
数据来源: Karger
摘要:
The amount of immunoglobulin-containing cells in gastric mucosa from 6 patients with Ménétriér’s disease was estimated. Furthermore, the rate of gastric epithelial cell proliferation was studied in 4 of the patients. Fluorescent antisera specifically reacting with IgA, IgG and IgM were applied, and accordingly the cells were differentiated and quantitated. Other biopsies were labelled in vitro with 3H-thymidine and autoradiographs were prepared. The percentage of DNA-synthesising cells in the progenitor cell region was estimated. The number of IgM-containing cells in the gastric fundic mucosa was markedly increased, while the rate of epithelial cell proliferation was increased in 2 cases and within normal range in the remaining 2 pati
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