Kinetics of hypogammaglobulinemia in patients with common variable immunodeficiency
作者:
Yoshihiro Kato,
Naomi Kondo,
Fumiaki Motoyoshi,
Takeshi Ozawa,
Hiroatsu Agata,
Tadao Orii,
期刊:
Acta Paediatrica
(WILEY Available online 1993)
卷期:
Volume 82,
issue 9
页码: 739-743
ISSN:0803-5253
年代: 1993
DOI:10.1111/j.1651-2227.1993.tb12549.x
出版商: Blackwell Publishing Ltd
关键词: Common variable immunodeficiency;(hypo) gammaglobulinemia
数据来源: WILEY
摘要:
We investigated the production of immunoglobulin (Ig) in six patients with common variable immunodeficiency and analyzed the courses of their levels of serum Ig for a period of 8–13 years. In all patients, levels of serum IgM, IgG and IgA were markedly low at the first examination, except for the IgM level in one patient. Improvement of serum Ig levels was observed in the patients in whom Ig production of non‐T cells at the first examination and Cμ gene expression had been detected to a slight degree, but serum Ig levels remained low in the patients in whom Ig production of non‐T cells and Cμ gene expression had not been detected. Our results suggest that some hypogammaglobulinemia in common variable immunodeficiency develops or improves w
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