An Accurate Procedure for the Analysis of Azithromycin in Ferret Feces Using Solid Phase Extraction and HPLC
作者:
L.S. Wigman,
R.T. Darrington,
J.W. Young,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 1998)
卷期:
Volume 21,
issue 6
页码: 819-828
ISSN:1082-6076
年代: 1998
DOI:10.1080/10826079808000511
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Azithromycin has become one of the most widely prescribed macrolide antibiotics due to the pharmacokinetic profile and broad spectrum of activity. A method for determining the level of azithromycin in ferret feces involving drying, methylene chloride extraction, solid phase extraction (SPE) clean-up, and HPLC analysis was developed. The method was linear from 0.8 to 3.2 mg/mL with a mean recovery of 97% (0.6% RSD for 50 mg spiked simulated feces). The analysis was developed to quantitate approximately 50 mg of azithromycin in approximately 0.6g of dried feces.
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