Syngeneic Small-Bowel Grafting Increases Susceptibility to Lethal Graft-versus-Host Disease in the Rat
作者:
E. Kobayashi,
N. Kamada,
S. Enosawa,
N. Toyama,
M. Miyata,
期刊:
European Surgical Research
(Karger Available online 1995)
卷期:
Volume 27,
issue 1
页码: 19-26
ISSN:0014-312X
年代: 1995
DOI:10.1159/000129368
出版商: S. Karger AG
关键词: Graft-versus-host disease;Small bowel transplantation;Surgical damage;Blood transfusion
数据来源: Karger
摘要:
The rat model has been used to present evidence of the effect of surgical damage on the immune system. Syngeneic small bowel transplantation (SBT) has been used to show an increased incidence of graft-versus-host disease (GVHD) as well as thymic atrophy and altered host T cell proliferative response. Syngeneic auxiliary SBT was carried out between (LEW × BN)Fι hybrids. Varying amounts of LEW mesenteric lymphocytes were injected into the last animals to induce GVHD. Results showed that in the SBT recipients the incidence of lethal GVHD was increased when compared with untreated or sham-laparotomy controls. Marked thymic atrophy was also observed, while the number of hepatic lymphocytes increased transiently. Lymphocyte proliferation in response to concanavalin A or interleukin-2 was impaired for up to 21 days postoperatively, whereas the mixed lymphocyte reaction reactivity was not affected. These results show that the number and proliferative activity of thymic T cells were impaired after major small bowel transplantation surgery and that extrathymic lymphocytes were developed in the live
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