Molecular mechanisms of protease‐mediated tumor invasiveness
作者:
Francesco Blasl,
期刊:
Journal of Surgical Oncology
(WILEY Available online 1993)
卷期:
Volume 53,
issue S3
页码: 21-23
ISSN:0022-4790
年代: 1993
DOI:10.1002/jso.2930530507
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: urokinase;receptors;invasiveness;metastasis
数据来源: WILEY
摘要:
AbstractThe biochemical, regulatory, and physiological aspects of plasmin formation by the urokinase‐type plasminogen activator (uPA) is discussed and its involvement in cancer malignancy analyzed. Cell surface plasminogen activation has been shown to be essential in extracellular matrix degradation, basement membrane dissolution, and cancer invasiveness and metastasis in a variety of model systems. The ability of cells to produce plasmin on their surface depends on the presence of uPA and plasminogen receptors, and is the basis of the regulation of the plasminogen activating system in vivo. © 1993 Wiley‐Liss,
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