Oxygen Radicals Induce Pulmonary Vasoconstriction in Pigs without Activating Plasma Proteolytic Cascade Systems
作者:
J. Sanderud,
O.D. Saugstad,
期刊:
European Surgical Research
(Karger Available online 1993)
卷期:
Volume 25,
issue 3
页码: 137-145
ISSN:0014-312X
年代: 1993
DOI:10.1159/000129268
出版商: S. Karger AG
关键词: Allopurinol;Catalase;Indomethacin;Plasma prekallikrein;Pulmonary hemodynamics;Oxygen radicals;Xanthine oxidase
数据来源: Karger
摘要:
The effects of infusion of the oxygen radical generating system, hypoxanthine-xanthine oxidase, on pulmonary hemodynamics and plasma proteolytic systems, as the plasma kallikrein-kinin and fibrinolytic systems, were studied in pigs by infusion of xanthine oxidase into the pulmonary circulation. A marked pulmonary vasoconstriction and increase in vasculatur resistance with a maximum after 25 min was observed. The effects were attenuated by indomethacin, allopurinol and catalase. During the 130-min observation time there were no signs indicating activation of either the plasma kallikrein or the plasma fibrinolytic systems.
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