Variations in Urinary Levels of Free 6β-Hydroxycortisol, Cortisol, and Estrogens in Late Pregnancy
作者:
David J.S. Hunter,
Paul Keane,
Christopher Walker,
Edward V. YoungLai,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1984)
卷期:
Volume 18,
issue 2
页码: 83-87
ISSN:0378-7346
年代: 1984
DOI:10.1159/000299054
出版商: S. Karger AG
关键词: 6β-Hydroxycortisol;Cortisol;Estrogen;Diurnal rhythm;Pregnancy urine
数据来源: Karger
摘要:
The urinary excretion of 6β-hydroxycortisol (6β-OHF), free cortisol, and estriol was studied at 4-hourly intervals in 9 subjects between the 36th and 38th week of pregnancy. The ratio of 6β-OHF to creatinine showed a significant diurnal rhythm with a 40% fall from a peak at 06.00–10.00 h to a trough at 22.00–02.00 h. There was a significant positive correlation between the excretion of 6β-OHF and free cortisol. Estrogen excretion showed no diurnal variation. No increase was observed in the 6β-OHF:creatinine ratio in early morning urine samples from 5 subjects followed daily prior to the onset of spontaneous labour at term. Normal nonpregnant females were also found to excrete significant quantities of 6β-OHF. These findings suggest that the clinical significance of 6β-OHF levels measured in a single void sample of urine has to be reassessed in the face of such a marked diurnal variation.
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