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PMR Assay of Natural Products in Pharmaceuticals. IV Assay of Codeine and Simultaneous Detection of Morphine

 

作者: ElsayedA. Aboutabl,   JaberS. Mossa,   M.M. A. Hassan,  

 

期刊: Spectroscopy Letters  (Taylor Available online 1979)
卷期: Volume 12, issue 7-8  

页码: 579-590

 

ISSN:0038-7010

 

年代: 1979

 

DOI:10.1080/00387017908069181

 

出版商: Taylor & Francis Group

 

关键词: Codeine, PMR spectroscopic analysis in bulk drug and tablets;PMR spectroscopy, analysis, codeine in bulk drug and tablets;Morphine, PMR spectroscopic analysis, detection in codeine.

 

数据来源: Taylor

 

摘要:

A rapid, accurate and precise PMR method is presented for the quantitative determination of codeine and codeine phosphate as bulk drugs and in tablet dosage form. The determination is based on the integration of the C-3 methylprotons or the two aromatic protons of codeine or its salt relative to that of the nine protons of t-butanol. Standard deviations of ± 1.39, 0.27 and 0.65% were obtained for codeine, codeine phosphate bulk drug and codeine phosphate tablets respectively. The method furnishes a specific means of identification of codeine as well as of the simultaneous detection and possible determination of morphine; thus fulfilling one of the most important pharmacopeial requirements for the purity of codeine.

 

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