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Interleukin-2 Inhibits Growth of Fibroblasts Derived from Human Bone Marrow

 

作者: D. MacDonald,   J.A. Adams,   D. McCarthy,   A.J. Barrett,  

 

期刊: Acta Haematologica  （Karger Available online 1990）
卷期: Volume 83, issue 1  

页码: 26-30

 

ISSN:0001-5792

 

年代: 1990

 

DOI:10.1159/000205158

 

出版商: S. Karger AG

 

关键词: Fibroblast colony-forming cells;Haematopoiesis;γ-Interferon;Interleukin-2

 

数据来源: Karger

 

摘要:

The adherent layer that forms in human bone marrow suspension cultures contains fibroblast colonies which arise from colony-forming cells (CFU-F). We have demonstrated that recombinant interleukin-2 (r-IL2) inhibits growth of CFU-F by preventing their entry into S phase. This inhibition is not mediated by γ-interferon, nor by T lymphocytes, and can be abrogated by anti-IL2 receptor antibody. r-IL2 may influence haematopoiesis by its effect on bone marrow CFU-F

 

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