Sudden Sensorineural Hearing Loss Induced by Experimental Iron Deficiency in Rats
作者:
Ai-Hua Sun,
Zheng-Min Wang,
Shi-Zhi Xiao,
Zhao-Ji Li,
Zun Zheng,
Jin-Ying Li,
期刊:
ORL
(Karger Available online 1992)
卷期:
Volume 54,
issue 5
页码: 246-250
ISSN:0301-1569
年代: 1992
DOI:10.1159/000276307
出版商: S. Karger AG
关键词: Iron deficiency;Sudden hearing loss;Succinic dehydrogenase;Spiral ganglion cells;Hair cells
数据来源: Karger
摘要:
The relation between iron deficiency (ID) and sudden sensorineural hearing loss (SSHL) was evaluated in the growing rats of three different experimental groups. Fourteen rats of 132 (10.61%) that were raised on a basic ID diet showed SSHL in varied extent, from moderate to profound. By contrast, none of 128 standard control and 126 anemic control rats that were fed with the final iron-supplemented diet showed any degree of SSHL. The main cochlear correlates of SSHL in ID rats were synchronous abnormalities of the iron-containing enzymatic activity in the whole cochlea, a significant reduction of spiral ganglion cells and a rapid involvement of stereocilia of the outer and inner hair cells. The results suggest that ID can play a major role in the pathogenesis of SSHL.
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