Gender differences in perception of risk associated with use of alcohol and other drugs were assessed amone a samole of 1,244 undergraduates at a major Pacific Northwest Gversity. Reexamination of data from a self-administered questionnaire revealed that females were more likely than males to perceive greater risk with use of alcohol and other dmgs. In particular, female perceptions of risk were significantly different from males (P<.001) for most levels of alcohol use and for perception of risk for occasional use of psychedelics, heroin, and dieipills.-Our fmdings suggest the need for continued gender-specific research (and health education) in substance abuse prevention.